KHVD(Koi Herpes Virus Disease)

 【English】
                              A B C D E G H I K M N O P R S T U W X Y Japanese 
                                              
Adkison, M. A., O. Gilad, and R. P. Hedrick. 2005. An enzyme linked immunosorbent assay (ELISA) for detection of antibodies to the koi herpesvirus (KHV) in the serum of koi Cyprinus carpio. Fish Pathology 40:53-62.
Amita, K., M. Oe, H. Matoyama, N. Yamaguchi, and H. Fukuda. 2002. A survey of koi herpesvirus and carp edema virus in colorcarp cultured in Niigata Prefecture, Japan. Fish Pathology 37:197-198.
Antychowicz, J., M. Reichert, M. Matras, S. M. Bergmann, and O. Haenen. 2005. Epidemiology, pathogenicity and molecular biology of Koi herpesvirus isolated in Poland. Bulletin of the Veterinary Institute in Pulawy 49:367-373.
Aoki, T., I. Hirono, and H. Kondo. 2005. Characterization of gene structure of koi herpesvirus by genome analysis. Fish Pathology 40:205-205.
Aoki, T., I. Hirono, K. Kurokawa, H. Fukuda, R. Nahary, A. Eldar, A. J. Davison, T. B. Waltzek, H. Bercovier, and R. P. Hedrick. 2007. Genome sequences of three koi herpesvirus isolates representing the expanding distribution of an emerging disease threatening koi and common carp worldwide. Journal of Virology 81:5058-5065.
Aoki, T., Takano, T., Unajak, S., Takagi, M., Kim, Y.R., Park, S.B., Kondo, H., Hirono, I., Saito-Taki, T., Hikima, J.-i., Jung, T.S., Generation of monoclonal antibodies specific for ORF68 of koi herpesvirus. Comparative Immunology, Microbiology and Infectious Diseases in Press,

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Bercovier, H., Fishman, Y., Nahary, R., Sinai, S., Zlotkin, A., Eyngor, M., Gilad, O., Eldar, A., Hedrick, R.P. 2005. Cloning of the koi herpesvirus (KHV) gene encoding thymidine kinase and its use for a highly sensitive PCR based diagnosis. BMC Microbiol 5:13.
Bergmann, S. M., J. Kempter, J. Sadowski, and D. Fichtner. 2006. First detection, confirmation and isolation of koi herpesvirus (KHV) in cultured common carp (Cyprinus carpio L.) in Poland. Bulletin of the European Association of Fish Pathologists 26:97-104.
Bergmann, S.M., Riechardt, M., Fichtner, D., Lee, P., Kempter, J. 2010. Investigation on the diagnostic sensitivity of molecular tools used for detection of koi herpesvirus. Journal of Virological Methods 163, 229-233.
BigarrE, L., Baud, M., Cabon, J., Antychowicz, J., Bergmann, S.M., Engelsma, M., Pozet, F., Reichert, M., Castric, J. 2009. Differentiation between Cyprinid herpesvirus type-3 lineages using duplex PCR. Journal of Virological Methods 158:51-57.
Biwako-Handbook-Editors-Commission (ed.). 2007. Biwako Handbook. Shiga Prefecture, Otsu.
Bocklisch, H., U. Landsiedel, and B. Dresenkamp. 2006. Outbreak of koi herpesvirus infection in carps in Northern Thuringia. Tierarztliche Praxis Ausgabe G: Grosstiere - Nutztiere 34:121-125.
Bretzinger, A., Fischer-Scherl, T., Oumouna, M., Hoffmann, R., Truyen, U. 1999. Mass mortalities in koi, Cyprinus carpio, associated with gill and skin disease. Bulltein of European Association of Fish Pathologists 19:182.

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Costes, B., G. Fournier, B. Michel, C. Delforge, V. S. Raj, B. Dewals, L. Gillet, P. Drion, A. Body, F. Schynts, F. Lieffrig, and A. Vanderplasschen. 2008. Cloning of the koi herpesvirus genome as an infectious bacterial artificial chromosome demonstrates that disruption of the thymidine kinase locus induces partial attenuation in Cyprinus carpio koi. Journal of Virology 82:4955-4964.
Costes, B., V. S. Raj, B. Michel, G. Fournier, M. Thirion, L. Gillet, J. Mast, F. Lieffrig, M. Bremont, and A. Vanderplasschen. 2009. The major portal of entry of koi herpesvirus in Cyprinus carpio is the skin. Journal of Virology 83:2819-2830.

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Davidovich, M., Dishon, A., Ilouze, M., Kotler, M. 2007. Susceptibility of cyprinid cultured cells to cyprinid herpesvirus 3. Archives of Virology 152:1541-1546.
Denham, K. 2003. Koi herpesvirus in wild fish. Veterinary Record 153:507.
Dishon, A., M. Davidovich, M. Ilouze, and M. Kotler. 2007. Persistence of cyprinid herpesvirus 3 in infected cultured carp cells. Journal of Virology 81:4828-4836.
Dishon, A., A. Perelberg, J. Bishara-Shieban, M. Ilouze, M. Davidovich, S. Werker, and M. Kotler. 2005. Detection of carp interstitial nephritis and gill necrosis virus in fish droppings. Applied and Environmental Microbiology 71:7285-7291.

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El-Matbouli, M., U. Rucker, and H. Soliman. 2007. Detection of Cyprinid herpesvirus-3 (CyHV-3) DNA in infected fish tissues by nested polymerase chain reaction. Diseases of Aquatic Organisms 78:23-28.
El-Matbouli, M., Saleh, M., Soliman, H., 2007. Detection of cyprinid herpesvirus type 3 in goldfish cohabiting with CyHV-3-infected koi carp (Cyprinus carpio koi). Vet Rec 161:792-793.
El-Matbouli, M., Soliman, H., Transmission of Cyprinid herpesvirus-3 (CyHV-3) from goldfish to naive common carp by cohabitation. Research in Veterinary Science in Press.

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Garver, K.A., Al-Hussinee, L., Hawley, L.M., Schroeder, T., Edes, S., LePage, V., Contador, E., Russell, S., Lord, S., Stevenson, R.M.W., Souter, B., Wright, E., Lumsden, J.S. 2010. Mass mortality associated with koi herpesvirus in wild common carp in Canada. Journal of Wildlife Diseases 46: 1242-1251.
Gilad, O., S. Yun, K. B. Andree, M. A. Adkison, A. Zlotkin, H. Bercovier, A. Eldar, and R. P. Hedrick. 2002. Initial characteristics of koi herpesvirus and development of a polymerase chain reaction assay to detect the virus in koi, Cyprinus carpio koi. Diseases of Aquatic Organisms 48:101-108.
Gilad, O., S. Yun, M. A. Adkison, K. Way, N. H. Willits, H. Bercovier, and R. P. Hedrick. 2003. Molecular comparison of isolates of an emerging fish pathogen, koi herpesvirus, and the effect of water temperature on mortality of experimentally infected koi. Journal of General Virology 84:2661-2668.
Gilad, O., S. Yun, F. J. Zagmutt-Vergara, C. M. Leutenegger, H. Bercovier, and R. P. Hedrick. 2004. Concentrations of a Koi herpesvirus (KHV) in tissues of experimentally infected Cyprinus carpio koi as assessed by real-time TaqMan PCR. Diseases of Aquatic Organisms 60:179-187.
Goodwin, A. E., G. E. Merry, and J. Sadler. 2006. Detection of the herpesviral hematopoietic necrosis disease agent (Cyprinid herpesvirus 2) in moribund and healthy goldfish: validation of a quantitative PCR diagnostic method. Diseases of Aquatic Organisms 69:137-143.
Gray, W. L., L. Mullis, S. E. LaPatra, J. M. Groff, and A. Goodwin. 2002. Detection of koi herpesvirus DNA in tissues of infected fish. Journal of Fish Diseases 25:171-178.
Grimmett, S. G., J. V. Warg, R. G. Getchell, D. J. Johnson, and P. R. Bowser. 2006. An unusual Koi herpesvirus associated with a mortality event of common carp Cyprinus carpio in New York State, USA. Journal of Wildlife Diseases 42:658-662.
Gunimaladevi, I., T. Kono, M. N. Venugopal, and M. Sakai. 2004. Detection of koi herpesvirus in common carp, Cyprinus carpio L., by loop-mediated isothermal amplification. Journal of Fish Diseases 27:583-589.

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Haenen, O. L. M., K. Way, S. M. Bergmann, and E. Ariel. 2004. The emergence of koi herpesvirus and its significance to European aquaculture. Bulletin of the European Association of Fish Pathologists 24:293-307.
Haenen, O., Hedrick, R. 2006. Koi herpesvirus workshop. Bulletin of the European Association of Fish Pathologists 26:26-37.
Hara, H., H. Aikawa, K. Usui, and T. Nakanishi. 2006. Outbreaks of koi herpesvirus disease in rivers of Kanagawa Prefecture. Fish Pathology 41:81-83.
Haramoto, E., M. Kitajima, H. Katayama, and S. Ohgaki. 2007. Detection of koi herpesvirus DNA in river water in Japan. Journal of Fish Diseases 30:59-61.
Haramoto, E., Kitajima, M., Katayama, H., Ito, T., Ohgaki, S. 2009. Development of virus concentration methods for detection of koi herpesvirus in water. Journal of Fish Diseases 32:297-300.
Hartman, K.H., Yanong, R.P.E., Petty, B.D., Francis-Floyd, R., Riggs, A.C. 2004. Koi herpes virus (KHV) disease. University of Florida IFAS extension 149:1-8.
Hedrick, R. P., J. M. Groff, M. S. Okihiro, and T. S. McDowell. 1990. Herpesviruses detected in papillomatous skin growths of koi carp (Cyprinus carpio). Journal of Wildlife Diseases 26:578-581.
Hedrick, R. P., O. Gilad, S. Yun, J. V. Spangenberg, G. D. Marty, R. W. Nordhausen, M. J. Kebus, H. Bercovier, and A. Eldar. 2000. A herpesvirus associated with mass mortality of juvenile and adult koi, a strain of common carp. Journal of Aquatic Animal Health 12:44-57.
Hedrick, R. P., O. Gilad, S. C. Yun, T. S. McDowell, T. B. Waltzek, G. O. Kelley, and M. A. Adkison. 2005. Initial isolation and characterization of a herpes-like virus (KHV) from koi and common carp. Bulletin of Fisheries Research Agency Suppl. 2:1-7.
Hedrick, R. P., T. B. Waltzek, and T. S. McDowell. 2006. Susceptibility of koi carp, common carp, goldfish, and goldfish x common carp hybrids to cyprinid herpesvirus-2 and herpesvirus-3. Journal of Aquatic Animal Health 18:26-34.
Honjo, M. N., T. Minamoto, K. Matsui, K. Uchii, H. Yamanaka, A. A. Suzuki, Y. Kohmatsu, T. Iida, and Z. Kawabata. 2010. Quantification of cyprinid herpesvirus 3 in environmental water by using an external standard virus. Appl. Environ. Microbiol. 76:161-168.(★)
Hutoran, M., A. Ronen, A. Perelberg, M. Ilouze, A. Dishon, I. Bejerano, N. Chen, and M. Kotler. 2005. Description of an as yet unclassified DNA virus from diseased Cyprinus carpio species. Journal of Virology 79:1983-1991.

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Ilouze, M., Davidovich, M., Diamant, A., Kotler, M., Dishon, A., The outbreak of carp disease caused by CyHV-3 as a model for new emerging viral diseases in aquaculture: a review. in Press.
Ilouze, M., A. Dishon, T. Kahan, and M. Kotler. 2006. Cyprinid herpes virus-3 (CyHV-3) bears genes of genetically distant large DNA viruses. FEBS Letters 580:4473-4478.
Ilouze, M., A. Dishon, and M. Kotler. 2006. Characterization of a novel virus causing a lethal disease in carp and koi. Microbiology and Molecular Biology Reviews 70:147-156.
Ishioka, T., M. Yoshizumi, S. Izumi, K. Suzuki, H. Suzuki, K. Kozawa, M. Arai, K. Nobusawa, Y. Morita, M. Kato, T. Hoshino, T. Iida, K. Kosuge, and H. Kimura. 2005. Detection and sequence analysis of DNA polymerase and major envelope protein genes in koi herpesviruses derived from Cyprinus carpio in Gunma prefecture, Japan. Veterinary Microbiology 110:27-33.
Ito, T., M. Sano, J. Kurita, K. Yuasa, and T. Iida. 2007. Carp larvae are not susceptible to Koi herpesvirus. Fish Pathology 42:107-109.

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Kasai, H., Y. Muto, and M. Yoshimizu. 2005. Virucidal effects of ultraviolet, heat treatment and disinfectants against koi herpesvirus (KHV). Fish Pathology 40:137-138.
Kempter, J., Sadowski, J., Schutze, H., Fischer, U., Dauber, M., Fichtner, D., Panicz, R., Bergmann, S.M. 2009. Koi Herpes Virus: Do Acipenserid Restitution Programs Pose a Threat to Carp Farms in the Disease-Free Zones? Acta Ichthyologica Et Piscatoria 39:119-126.
Kielpinski, M., J. Kempter, R. Panicz, J. Sadowski, H. Schutze, S. Ohlemeyer, and S. M. Bergmann. 2010. Detection of KHV in Freshwater Mussels and Crustaceans from Ponds with KHV History in Common Carp (Cyprinus carpio). Israeli Journal of Aquaculture-Bamidgeh 62:28-37.
Kurita, J., K. Yuasa, T. Ito, M. Sano, R. P. Hedrick, M. Y. Engelsma, O. L. M. Haenen, A. Sunarto, E. B. Kholidin, H.-Y. Chou, M.-C. Tung, L. d. l. Pena, G. Lio-Po, C. Tu, K. Way, and T. Iida. 2009. Molecular Epidemiology of Koi Herpesvirus. Fish Pathology 44:59-66.

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Matsui, K., M. Honjo, Y. Kohmatsu, K. Uchii, R. Yonekura, and Z. Kawabata. 2008. Detection and significance of koi herpesvirus (KHV) in freshwater environments. Freshwater Biology 53:1262-1272.(★)
Michel, B., G. Fournier, F. Lieffrig, B. Costes, and A. Vanderplasschen. 2010. Cyprinid herpesvirus 3. Emerging Infectious Diseases 16:1835-1843.
Michel, B., Leroy, B., Stalin Raj, V., Lieffrig, F., Mast, J., Wattiez, R., Vanderplasschen, A.F., Costes, B. 2010. The genome of cyprinid herpesvirus 3 encodes 40 proteins incorporated in mature virions. Journal of General Virology 91:452-462.
Minamoto, T., Honjo, M.N., Kawabata, Z. 2009. Seasonal Distribution of Cyprinid Herpesvirus 3 in Lake Biwa, Japan. Applied and Environmental Microbiology 75:6900-6904.(★)
Minamoto, T., M. N. Honjo, K. Uchii, H. Yamanaka, A. A. Suzuki, Y. Kohmatsu, T. Iida, and Z. Kawabata. 2009. Detection of cyprinid herpesvirus 3 DNA in river water during and after an outbreak. Veterinary Microbiology 135:261-266.(★)
Minamoto, T., M. N. Honjo, H. Yamanaka, N. Tanaka, T. Itayama,Z.Kawabata. Detection of cyprinid herpesvirus-3 DNA in lake plankton. Res Vet Sci.in Press.(★)
Miyazaki, T., Y. Kuzuya, S. Yasumoto, M. Yasuda, T. Kobayashi. 2008. Histopathological and ultrastructural features of Koi herpesvirus (KHV)-infected carp Cyprinus carpio, and the morphology and morphogenesis of KHV. Diseases of Aquatic Organisms 80:1-11.

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Nakajima, K. 2004. International Symposium on Koi Herpesvirus Disease: Strategy for koi herpesvirus disease control. Nippon Suisan Gakkaishi 70:615.
Neuhaus, H., and K. Meyer. 2006. Koi herpesvirus infection of carp (Cyprinus carpio L.). Kleintierpraxis 51:521-526.
Neukirch, M., Boettcher, K., Sumrarn, B. 1999. Isolation of a virus from koi with altered gills. Bulletin of the European Association of Fish Pathologists 19:221.

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Oh, M. J., S. J. Jung, T. J. Choi, H. R. Kim, K. V. Rajendran, Y. J. Kim, M. A. Park, and S. K. Chun. 2001. A viral disease occurring in cultured carp Cyprinus carpio in Korea. Fish Pathology 36:147-151.
Omori, R., Adams, B. 2011. Disrupting seasonality to control disease outbreaks: The case of koi herpes virus. Journal of Theoretical Biology 271:159-165

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Pearson, H. 2004. Carp virus crisis prompts moves to avert global spread. Nature 427:577.
Perelberg, A., M. Smirnov, M. Hutoran, A. Diamant, Y. Bejerano, and M. Kotler. 2003. Epidemiological description of a new viral disease afflicting cultured Cyprinus carpio in Israel. Israeli Journal of Aquaculture-Bamidgeh 55:5-12.
Perelberg, A., A. Ronen, M. Hutoran, Y. Smith, and M. Kotler. 2005. Protection of cultured Cyprinus carpio against a lethal viral disease by an attenuated virus vaccine. Vaccine 23:3396-3403.
Perelberg, A., M. Ilouze, M. Kotler, and M. Steinitz. 2008. Antibody response and resistance of Cyprinus carpio immunized with cyprinid herpes virus 3 (CyHV-3). Vaccine 26:3750-3756.
Philbey, A. W. 2006. Herpesvirus haematopoietic necrosis in a goldfish (Carassius auratus) in the UK. Veterinary Record 158:800-801.
Pikarsky, E., A. Ronen, J. Abramowitz, B. Levavi-Sivan, M. Hutoran, Y. Shapira, M. Steinitz, A. Perelberg, D. Soffer, and M. Kotler. 2004. Pathogenesis of acute viral disease induced in fish by carp interstitial nephritis and gill necrosis virus. Journal of Virology 78:9544-9551.
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Pokorova, D., T. Vesely, V. Piackova, S. Reschova, and J. Hulova. 2005. Current knowledge on koi herpesvirus (KHV): a review. Veterinarni Medicina 50:139-147.

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Rakus, K. L., G. F. Wiegertjes, M. Adamek, A. K. Siwicki, A. Lepa, and I. Irnazarow. 2009. Resistance of common carp (Cyprinus carpio L.) to Cyprinid herpesvirus-3 is influenced by major histocompatibility (MH) class II B gene polymorphism. Fish and Shellfish Immunology 26:737-743.
Ronen, A., A. Perelberg, J. Abramowitz, M. Hutoran, S. Tinman, I. Bejerano, M. Steinitz, and M. Kotler. 2003. Efficient vaccine against the virus causing a lethal disease in cultured Cyprinus carpio. Vaccine 21:4677-4684.
Rosenkranz, D., Klupp, B.G., Teifke, J.P., Granzow, H., Fichtner, D., Mettenleiter, T.C., Fuchs, W. 2008. Identification of envelope protein pORF81 of koi herpesvirus. J Gen Virol 89:896-900.

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Sadler, J., Marecaux, E., Goodwin, A.E. 2008. Detection of koi herpes virus (CyHV-3) in goldfish, Carassius auratus (L.), exposed to infected koi. Journal of Fish Diseases 31:71-72.
Sano, M., Ito, T., Kurita, J., Miwa, S., Iida, T. 2005. Diagnosis of Koi Herpesvirus (KHV) Disease in Japan. Bull Fish Res Agen Suppl 2:59-64.
Sano, M., T. Ito, J. Kurita, T. Yanai, N. Watanabe, S. Miwa, and T. Iida. 2004. First detection of koi herpesvirus in cultured common carp Cyprinus carpio in Japan. Fish Pathology 39:165-167.
Schlotfeldt, H. F. 2004. Severe losses of common carp in Germany due to Koi Herpesvirus (KHV). Bulletin of the European Association of Fish Pathologists 24:216-217.
Shapira, Y., Magen, Y., Zak, T., Kotler, M., Hulata, G., Levavi-Sivan, B. 2005. Differential resistance to koi herpes virus (KHV)/carp interstitial nephritis and gill necrosis virus (CNGV) among common carp (Cyprinus carpio L.) strains and crossbreds. Aquaculture 245:1-11.
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Tan, A.-p., Zou, W.-m., Zhao, F., Chen, X.-l., Lao, H.-h., Jian, Q., Lu, X.-d., Luo, L. 2008. PCR amplification and sequence analysis of the major envelop protein gene of KHV. Journal of Fishery Sciences of China 15:880-884.
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Uchii, K., K. Matsui, T. Iida, and Z. Kawabata. 2009. Distribution of the introduced cyprinid herpesvirus 3 in a wild population of common carp, Cyprinus carpio L. Journal of Fish Diseases 32:857-864.(★)
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Walster, C. I. 1999. Clinical observations of severe mortalities in koi carp, Cyprinus carpio, with gill disease. Fish Veterinary Journal 3:54-58.
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Yamamura, N., A. Telschow, K. Uchii, and Z. Kawabata. 2011. A basic equation for population dynamics with destruction of breeding habitats and its application to outbreak of cyprinid herpesvirus 3. Ecological Research 26:181-189.(★)
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80.
Yuasa, K., M. Sano, J. Kurita, T. Ito, and T. Iida. 2005. Improvement of a PCR method with the Sph I-5 primer set for the detection of koi herpesvirus (KHV). Fish Pathology 40:37-39.
Yuasa, K., T. Ito, and M. Sano. 2008. Effect of Water Temperature on Mortality and Virus Shedding in Carp Experimentally Infected with Koi Herpesvirus. Fish Pathology 43:83-85.





 【Japanese】
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独立行政法人水産総合研究センター 「野生型及び飼育型コイのコイヘルペスウイルスに対する感受性の比較」
飯田 貴次 2005 「コイヘルペスウイルス病」『日本水産学会誌』71:632-635.
PDF: http://www.jstage.jst.go.jp/article/suisan/71/4/632/_pdf/-char/ja/
飯田 貴次・佐野 元彦 ほか 2005 「コイヘルペスウイルス病」『ウイルス』1:145-152.
川端 善一郎 2010 「コイヘルペスウィルス感染症」『地球環境学事典』pp.284-285.(★)
農林水産省 2006 「KHV病感染コイの発見状況総括表」 第9回コイヘルペスウイルス病に関する技術検討会.
大島 俊一郎・平山 健史・斉藤 照生 2008 「魚類のヘルペスウィルス感染症」『日本臨床』64巻増刊3号: 113-117.
滋賀県水産試験場 2006 「平成18年春季の琵琶湖におけるコイヘルペスウイルス(KHV)病の発生予測」
内井 喜美子・川端 善一郎 2009 「コイヘルペスウィルス病の侵入を外来種問題として捉える」『陸水学雑誌』70: 267-272.(★)
吉岡 剛 2005 「滋賀県でのコイヘルペスウイルス(KHV)の発生状況」平成16年度滋賀県水産試験場事業報告:64.



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